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Article

Genome-wide association study of positive and negative affect reveals shared genetic architecture and a potential causal relationship with cognition.

Scientific reports - 25 May 2026

Slaney Chloe, Mac Giollabhui Naoise, van der Most Peter J, Palacios Ensor R, Snieder Harold, Nivard Michel, Hemani Gibran, Hartman Catharina A, Khandaker Golam M

Abstract excerpt

Altered affect and cognitive dysfunction are burdensome features of many neuropsychiatric conditions that are highly comorbid, remain poorly understood, and have few efficacious treatments. Exploring their genetic architecture and causal relationships may provide insight into their aetiology and comorbidity. Compared to related but distinct traits (depression, wellbeing, neuroticism), findings from genome-wide...

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PMID: 42185370
DOI: 10.1038/s41598-026-51734-1
PMCID: PMC13439573

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GCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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