Article
Reporting framework in the testing of predisposition to common adult solid tumors using next-generation sequencing.
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti - 1 Jan 2026
Soukupová J, Koudová M, Foretová L, Krutílková V, Curtisová V, Blaháková I, Dolinová I, Dušková P, Faldynová L, Fišer M, Friedová N, Gančarčíková M, Chvojka Š, Janatová M, Janíková M, Kleiblová P, Kyselová K, Macháčková E, Měch R, Michalovská R, Nečesánková M, Spurná Z, Šedinová M, Šenkeříková M, Šimková Z, Šimová J, Šubrt I, Tavandzis S, Tesner P, Turňová J, Vlčková Z, Vočka M, Czecanca Konsorcium, Pracovní Skupina Onkogenetika Slg Čls Jep N/A, Kleibl Z
Abstract excerpt
BACKGROUND: Genetic testing for hereditary predisposition to solid tumors using next generation sequencing enables the analysis of a broad spectrum of genes and significantly increases diagnostic yield. However, expanding the scope of analyzed genomic regions also increases the likelihood of identifying so-called secondary findings, defined as pathogenic or likely pathogenic variants in genes unrelated to the...
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