Article
Validation of CZECANCA (CZEch CAncer paNel for Clinical Application) for targeted NGS-based analysis of hereditary cancer syndromes.
PloS one - 1 Jan 2018
Soukupova Jana, Zemankova Petra, Lhotova Klara, Janatova Marketa, Borecka Marianna, Stolarova Lenka, Lhota Filip, Foretova Lenka, Machackova Eva, Stranecky Viktor, Tavandzis Spiros, Kleiblova Petra, Vocka Michal, Hartmannova Hana, Hodanova Katerina, Kmoch Stanislav, Kleibl Zdenek
Abstract excerpt
BACKGROUND: Carriers of mutations in hereditary cancer predisposition genes represent a small but clinically important subgroup of oncology patients. The identification of causal germline mutations determines follow-up management, treatment options and genetic counselling in patients' families. Targeted next-generation sequencing-based analyses using cancer-specific panels in high-risk individuals have been...
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