Article
Night shift work and the acceleration of chronic kidney disease onset: dose-response relationships, interactions with cardiometabolic genetic risk, and metabolomic mediators.
Scandinavian journal of work, environment & health - 1 Jul 2026
Cai Xianglian, Zhang Yiwei, Ye Ziliang, Zhang Yanjun, Yang Sisi, Gan Xiaoqin, Xiang Hao, Huang Yu, Wu Yiting, Chen Dan, Liang Xiaolong, Qin Xianhui, Zhang Yuanyuan
Abstract excerpt
OBJECTIVES: The association between night shift work and chronic kidney disease (CKD) risk remains uncertain. We investigated the associations of current/lifetime night shift work with incident CKD, assessed joint effects with genetic susceptibility, and explored the mediating roles of obesity and metabolomic alterations. METHODS: Utilizing UK Biobank data, current (N=242 721) and lifetime (N=63 659) night shift...
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