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Article

A Novel MSN Mutation Impairs CD4+ T cell Differentiation and Drives Autoantibody Production.

Journal of clinical immunology - 22 May 2026

Zhu Ke, Sun Bijun, Zhang Wenjun, Liu Luyao, Wang Wenjie, Wang Chenghao, Xiao Feifan, Zhou Qinhua, Wang Xiaochuan, Sun Jinqiao

Abstract excerpt

PURPOSE: To report a patient with a novel MSN mutation causing X-linked moesin-associated immunodeficiency (X-MAID) and investigate its pathogenic mechanisms. METHODS: Clinical and immunological data of the patient were collected. Autoantibody levels were measured using antigen microarrays. Whole-exome sequencing was performed to identify gene mutations. The stability of the mutant MSN protein was analyzed via...

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Identifiers

PMID: 42174291
DOI: 10.1007/s10875-026-02034-w
PMCID: PMC13391721

Genes

MSN
CD4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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