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Article

The Immunodeficiency Profile of Lymphocytes in the Patient with Moesin Gene Mutation During Different Infection.

Journal of clinical immunology - 11 Aug 2025

Liu Qian, Zhang Ai, Bai Yuxin, Yang Xinpu, Liu Xinglou, Yang Lu, Ying Yanqin, Luo Xiaoping, Fang Feng, Liu Chaohong

Abstract excerpt

PURPOSE: The Ezrin-Radixin-Moesin (ERM) family member moesin (MSN) plays a crucial role in reversibly linking F-actin to the cell membrane. Patients carrying MSN gene mutations consistently exhibit immunodeficiencies. However, due to the scarce number of reported cases worldwide, the mechanism by which MSN mutation leads to immune function defects remains unclear. This study aims to profile the immunological...

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Source

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Identifiers

PMID: 40788322
DOI: 10.1007/s10875-025-01899-7
PMCID: PMC12339625

Genes

MSN
BCR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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