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Article

Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis.

PloS one - 1 Jan 2016

Alves da Costa Thiago, Di Gangi Rosária, Thomé Rodolfo, Barreto Felisbino Marina, Pires Bonfanti Amanda, Lumi Watanabe Ishikawa Larissa, Sartori Alexandrina, Burger Eva, Verinaud Liana

Abstract excerpt

T cell maturation takes place within the thymus, a primary lymphoid organ that is commonly targeted during infections. Previous studies showed that acute infection with Paracoccidioides brasiliensis (Pb), the causative agent of paracoccidioidomycosis (PCM), promotes thymic atrophy that is associated with the presence of yeast cells in the organ. However, as human PCM is a chronic infection, it is imperative to...

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Identifiers

PMID: 27736987
DOI: 10.1371/journal.pone.0164745
PMCID: PMC5063316

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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