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Article

Complex correlations between mitochondrial DNA variants and gut microbiome in major depressive disorder: a genome-wide association analysis.

BMC psychiatry - 20 May 2026

Guan Xuan, Shen Xiao-Ling, Hao Yan-Ni, Dong Zai-Quan, Chen Jian-Min

Abstract excerpt

BACKGROUND: Gut microbiota disturbances and impaired mitochondrial function are both linked with the development of major depressive disorder (MDD). However, little is known about how they interact in MDD. METHODS: We used shotgun metagenomic sequencing to explore fecal microbiome based on 63 MDD patients and 30 healthy controls (HCs). Then we performed GWAS for the discriminative taxonomic features of gut...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42163161
DOI: 10.1186/s12888-026-08132-8
PMCID: PMC13366882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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