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Article

Gut microbiota and major depressive disorder: A bidirectional Mendelian randomization.

Journal of affective disorders - 1 Nov 2022

Chen Min, Xie Chao-Rong, Shi Yun-Zhou, Tang Tai-Chun, Zheng Hui

Abstract excerpt

BACKGROUND: Observational studies showed an association between gut microbiota and depression, but the causality relationship between them is unclear. We aimed to determine whether there is a bidirectional causal relationship between the composition of gut microbiota and major depressive disorders (MDD) and explore the role of gut microbiota in decreasing the risk of MDD. METHODS: Our two-sample Mendelian...

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PMID: 35961601
DOI: 10.1016/j.jad.2022.08.012

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