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Article

Cell-type specific effects of SARS-CoV-2 P252L mutation on nirmatrelvir sensitivity.

Antiviral research - 1 Jul 2026

Loison Sheryline, Chabert Mehdi, Gensous Constant, Constant Samuel, Huang Song, Tapparel Caroline, Clément Sophie

Abstract excerpt

The SARS-CoV-2 main protease (NSP5) is the target of the FDA approved Nirmatrelvir (NTV) antiviral. Substitutions in NSP5, such as the P252L mutation, have been reported in clinical isolates and raise questions regarding its potential role in drug resistance. Here, we show that the P252L effect on NTV susceptibility is dependent on the culture model. The mutation arises spontaneously in VeroE6 cells without...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42162876
DOI: 10.1016/j.antiviral.2026.106445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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