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Article

Age and Sex Differences in the Genetics of Cardiomyopathy.

Journal of cardiovascular translational research - 1 Dec 2023

Akinrinade Oyediran, Lesurf Robert, Lougheed Jane, Mondal Tapas, Smythe John, Altamirano-Diaz Luis, Oechslin Erwin, Mital Seema

Abstract excerpt

Cardiomyopathy has variable penetrance. We analyzed age and sex-related genetic differences in 1,397 cardiomyopathy patients (Ontario, UK) with whole genome sequencing. Pediatric cases (n = 471) harbored more deleterious protein-coding variants in Tier 1 cardiomyopathy genes compared to adults (n = 926) (34.6% vs 25.9% respectively, p = 0.0015), with variant enrichment in constrained coding regions. Pediatric...

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Share to Cardiomyopathies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37477868
DOI: 10.1007/s12265-023-10411-8
PMCID: PMC10721711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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