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Article

Genetic background and plasmid-associated contig profiles of the beta-2 toxin coding genes cpb2 and atypical cpb2 in Clostridium perfringens.

BMC genomics - 19 May 2026

Tian Xin, Zhao Guangming, Wu Ke, Zhao Haoyu, Wang Shaolin, Fox Edward M, Xie Yuxin, Jiao Yunjie, Hao Huafang, Chen Shengli, Huang Yong, Zhang Xinke, Yang Zengqi, Wang Juan

Abstract excerpt

BACKGROUND: Beta-2 toxin is considered an accessory toxin of C. perfringens encoded by both the cpb2 and atypical cpb2 (aty.cpb2) genes. However, the prevalence patterns and genomic backgrounds of cpb2/aty.cpb2 remain incompletely understood. RESULTS: In this study, we performed a large-scale comparative genomic analysis of 865 cpb2- or aty.cpb2-positive C. perfringens strains. Genetic variation was detected...

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PMID: 42157076
DOI: 10.1186/s12864-026-12925-2
PMCID: PMC13352928

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