HLA DRB1* and DQB1* alleles are associated with disease severity in patients with pemphigus vulgaris.

doi:10.1111/ijd.12418

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Article

HLA DRB1* and DQB1* alleles are associated with disease severity in patients with pemphigus vulgaris.

International journal of dermatology - 1 Feb 2015

Svecova Danka, Parnicka Zuzana, Pastyrikova Lucia, Urbancek Slavomir, Luha Jan, Buc Milan

Abstract excerpt

BACKGROUND: Pemphigus vulgaris (PV) is a rare autoimmune disease that involves the skin and mucosa. The etiology of PV is multifactorial and includes genetic, environmental, hormonal, and immunological factors. OBJECTIVES: The purpose of this study was to examine the relationships between human leukocyte antigen (HLA) class II alleles associated with PV and variations in the disease phenotype. METHODS: Forty-four...

Topics

Adolescent
Adult
Age of Onset
Aged
Aged, 80 and over
Alleles
Female
Genetic Predisposition to Disease
HLA-DQ beta-Chains
HLA-DRB1 Chains
Humans
Male
Middle Aged
Pemphigus
Phenotype
Severity of Illness Index
Sex Factors
Young Adult

Source

Open in PubMed

Identifiers

PMID: 24602055
DOI: 10.1111/ijd.12418

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