Article
Multi-omics integration of molecular genetics, cytogenetics and immunophenotyping: a novel prognostic model for immune landscape characterization and outcome prediction in Chinese patients with acute myeloid leukemia.
Frontiers in immunology - 1 Jan 2026
Li Fengli, Ding Yangyang, Feng Shanglong, Jin Yingzhao, Xie Beibei, Zhang Qing, Jiao Xunyi, Zhu Jinli, Zhang Wanqiu, Tao Qianshan, Wang Huiping, Wu Depei, Liu Xin, Zhai Zhimin
Abstract excerpt
Background: Current genetic risk stratification systems for acute myeloid leukemia (AML), including the 2017 European Leukemia Network (ELN), 2022 ELN, and 2023 China (CN) stratifications, inconsistently categorize key genetic variants such as CEBPA and FLT3-ITD. These systems also demonstrate limited applicability to Chinese patients, complicating clinical decision-making. This study optimized genetic...
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