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Article

Monocytes from patients with chronic non-bacterial osteomyelitis (CNO) exhibit increased 'classically activated' phenotypes and altered DNA methylation patterns.

Clinical immunology (Orlando, Fla.) - 1 Aug 2026

Carlsson Emil, Godoy-Tena Gerard, Morbach Henner, Girschick Hermann J, Dissanayake Dilan, Charras Amandine, Ballestar Esteban, Hedrich Christian M

Abstract excerpt

Chronic non-bacterial osteomyelitis (CNO) is a rare autoinflammatory bone disease primarily affecting children and adolescents. Reliable biomarkers for diagnosis, disease monitoring, and prediction of disease course are lacking. This study demonstrates that, when compared to healthy participants, the proportion of 'pro-inflammatory' CD14++CD16- 'classical' monocytes is elevated in patients with CNO, before and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42142821
DOI: 10.1016/j.clim.2026.110715

Genes

CD14
CD163L1
CDK6
HDAC10
HOXA9
MAP2
MAP3K6
RUNX3
RXRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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