Identification of SARS2, PKN1, and IL11RA as causally-associated genes for patients with gastric cancer via immune cell activity: A multi-omics Mendelian randomization study integrating GWAS, eQTL, and pQTL data.

Abstract excerpt

BACKGROUND: Gastric cancer (GC) is a highly heterogeneous gastrointestinal malignancy associated with poor prognosis. A comprehensive understanding of its molecular mechanisms is crucial for identifying novel therapeutic targets. This study employed a multi-omics Mendelian randomization (MR) approach to investigate the causal associations among gene expression, protein expression levels, and immune cells in GC...

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