Case Report: Evolution of a BRAF V600E-mutant papillary thyroid carcinoma from latissimus dorsi metastasis and squamous transformation to PD-L1 upregulation and effective immunotherapy.

Abstract excerpt

This case report describes an unusual clinical course of a patient with papillary thyroid carcinoma (PTC). The patient sequentially developed metastases to the cervical lymph nodes, lungs, pleura, and brain. Following tumor invasion into the latissimus dorsi muscle, a biopsy of this metastatic lesion revealed a BRAF V600E-mutant squamous cell carcinoma (SCC) phenotype indicating a high-grade dedifferentiation...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to B7-H1 Antigen
• Share to Carcinoma, Squamous Cell