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Article

Efficacy of buparlisib according to PIK3CA mutation status in recurrent or metastatic head and neck squamous cell carcinoma: A multicenter phase II trial.

Oral oncology - 1 Jul 2026

Gauduchon Thibault, Digue Laurence, Ferlay Céline, Treilleux Isabelle, Wang Qing, Attignon Valéry, Lefebvre Gautier, Kotecki Nuria, Daste Amaury, Even Caroline, Couchon-Thaunat Sophie, Guyennon Aurélie, Peyrade Frédéric, Cupissol Didier, You Benoît, Tourneau Christophe Le, Tabone-Eglinger Séverine, Garin Gwenaelle, Pérol David, Fayette Jérome

Abstract excerpt

BACKGROUND: The PI3K/AKT pathway activation is an independent marker of poor outcome in head and neck squamous-cell carcinoma (HNSCC), and involved in resistance to cetuximab. Molecular alterations in this pathway, particularly PIK3CA mutations, represent a key event of this dysregulation. Buparlisib is a pan-Class I PI3K inhibitor that inhibits tumor growth in HNSCC xenografts. METHODS: This phase II trial...

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Identifiers

PMID: 42127863
DOI: 10.1016/j.oraloncology.2026.108004

Genes

PIK3CA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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