Article
Transcriptome and plasma proteome analyses identify susceptibility genes and proteins for alcohol-related hepatocellular carcinoma.
Human genomics - 12 May 2026
Li Zhishuang, Liu Menghan, Li Jiacheng, Li Wuwei, Min Tingting, Pan Runsan, Wang Wenqi, Chen Zhangrong, Li Wei, Huang Runze
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified loci associated with alcohol-related hepatocellular carcinoma (ALD-HCC); however, most risk variants lie in noncoding regions and the downstream regulatory architecture remains incompletely characterized. Integrating genetically predicted transcriptomic and circulating proteomic signals may facilitate target prioritization and biomarker discovery....
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