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FoxP3 genetic variants and risk of non-small cell lung cancer in the Chinese Han population.

Gene - 1 Dec 2013

He Yan-Qi, Bo Qiao, Yong Wei, Qiu Zhi-Xin, Li Ya-Lun, Li Wei-Min

Abstract excerpt

CD4(+)CD25(+) regulatory T cell-mediated immunosuppression is one of the crucial mechanisms that tumor cells use to evade the immune system. The forkhead box P3 (FoxP3) gene regulates regulatory T-cell development and function and may modulate the susceptibility to non-small cell lung cancer (NSCLC). Because a single nucleotide polymorphism (SNP) within the FoxP3 gene (rs3761548 in the promoter region) is...

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PMID: 24035934
DOI: 10.1016/j.gene.2013.08.066

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