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Article

Optimization of Culture Conditions for Pyrroloquinoline Quinone-Overproducing Mutant Hyphomicrobium denitrificans and Its Skin Bioactive Properties.

Journal of microbiology and biotechnology - 8 May 2026

Lee Jiwon, Hwang Hyunjoo, Kim Gamin, Hinterdorfer Peter, Song Soyoun, Ko Kisung

Abstract excerpt

Pyrroloquinoline quinone (PQQ) is a water-soluble quinone derived from bacteria, known for its antioxidant properties and ability to enhance mitochondrial function. These characteristics make PQQ a promising bioactive molecule for anti-aging applications in dermatology. This study aimed to improve PQQ production by developing a UV-induced mutant strain and optimizing the culture medium, and to evaluate the...

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Identifiers

PMID: 42108737
DOI: 10.4014/jmb.2603.03038
PMCID: PMC13158751

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