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Article

Genetic analysis of pigment production in the fungus Exophiala dermatitidis mutant strains obtained via nontargeted UV mutagenesis.

G3 (Bethesda, Md.) - 10 Dec 2025

Chhoker Kamaldeep, Hausner Georg, Harris Steven D

Abstract excerpt

Exophiala dermatitidis is a polyextremotolerant black yeast species. E. dermatitidis produces 1,8-dihydroxynaphthalene (DHN) melanin via the polyketide synthase 1 (PKS1) pathway enabling it to survive harmful conditions. This study focused on random nontargeted mutagenesis to obtain albino (alb) and hyperpigmented (hyp) mutants. Notably, all 17 alb mutants possessed mutations in PKS1 whereas the 113...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40902103
DOI: 10.1093/g3journal/jkaf205
PMCID: PMC12693494

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