Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotype-dependent effects of IL-17A inhibitors on lipid profiles in moderate-to-severe plaque psoriasis: a retrospective cohort study.

Lipids in health and disease - 9 May 2026

Wu Chao, Wang Si-Fan, Li Dian-Mo, He Chun-Xia, Jin Hong-Zhong

Abstract excerpt

BACKGROUND: Psoriasis is associated with elevated cardiovascular risk, partly mediated through dyslipidemia and the interleukin-23/Th17 inflammatory axis. Interleukin-17A (IL-17A) inhibitors demonstrate superior dermatologic efficacy, but their effects on lipid metabolism remain controversial. Most previous studies analyzed lipid changes at the population level without stratifying by baseline lipid phenotypes....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal, Humanized
Share to Dyslipidemias

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-17

Share to Lipids

Share to Psoriasis

Share to Risk Factors

Share to Severity of Illness Index

Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 42104419
DOI: 10.1186/s12944-026-02974-7
PMCID: PMC13326451

Genes

TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotype-dependent effects of IL-17A inhibitors on lipid profiles in moderate-to-severe plaque psoriasis: a retrospective cohort study.PMID 42104419Read ↗

Mapping the Causal Landscape of Psoriasis: A Systematic Mendelian Randomization Evidence Synthesis and Development of the MR-PsO Atlas Platform.Semantic proximity Read ↗

Molecular Phenotyping Small (Asian) versus Large (Western) Plaque Psoriasis Shows Common Activation of IL-17 Pathway Genes but Different Regulatory Gene Sets.Semantic proximity Read ↗

Immunological liver-skin axis: a systemic Vγ4 <sup>+</sup> γδT17 cell response links psoriasis-like inflammation and MASLDSemantic proximity Read ↗

Transcriptome profiling unveils the role of cholesterol in IL-17A signaling in psoriasisSemantic proximity Read ↗

Elevated plasma triglycerides increase the risk of psoriasis: a cohort and Mendelian randomization study.Semantic proximity Read ↗

Cardiovascular Considerations and Implications for Treatment in Psoriasis: An Updated Review.Semantic proximity Read ↗

The relationship between blood lipid and risk of psoriasis: univariable and multivariable Mendelian randomization analysisSemantic proximity Read ↗

Histological Stratification of Thick and Thin Plaque Psoriasis Explores Molecular Phenotypes with Clinical Implications.Semantic proximity Read ↗

Association between IL-17A, IL-17F and IL-17RA gene polymorphisms and susceptibility to psoriasis and psoriatic arthritis: a meta-analysis.Semantic proximity Read ↗

Assessing the genetic associations between plasma lipidomic profiles and psoriasis vulgaris.Semantic proximity Read ↗

Influence of Genetic Polymorphisms on Response to Biologics in Moderate-to-Severe PsoriasisSemantic proximity Read ↗

Psoriasis and metabolic syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.