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Article

RNF43 deficiency activates YBX1-MYC-driven oxidative phosphorylation in pancreatic cancer.

Cancer letters - 1 Aug 2026

Qin Gengdu, Pan Penglin, Qin Yang, Wei Ruozheng, Zhao Yuhan, Fu Qixun, Yu Haixin, Liu Jiaying, Wu Heshui, Liu Zhiqiang, Zhou Yingke

Abstract excerpt

RNF43 is frequently inactivated by mutations in pancreatic ductal adenocarcinoma (PDAC), but the molecular mechanisms and therapeutic vulnerabilities associated with RNF43 loss remain poorly defined. Here, we demonstrate that RNF43 functions as an E3 ubiquitin ligase targeting YBX1 for degradation, thereby suppressing mitochondrial oxidative phosphorylation (OXPHOS). In RNF43-deficient PDAC models, stabilized...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42097492
DOI: 10.1016/j.canlet.2026.218560

Genes

RNF43
MYC
YBX1
IDH2
IDH3A
IGF2BP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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