Article
The case for evaluation of double mutant heat-labile toxin as an adjuvant to improve oral cholera vaccine immunogenicity.
Frontiers in immunology - 1 Jan 2026
Bourgeois A Louis, Scott Daniel A, Baqar Shahida, Tribble David R, Svennerholm Ann-Mari, Walker Richard I
Abstract excerpt
Cholera has re-emerged as a major global public health threat. Orally administered attenuated or inactivated vaccines offer protection against enteric pathogens such as Vibrio cholerae, and several World Health Organization-prequalified oral cholera vaccines are used globally as part of international cholera prevention and control measures. However, vaccine effectiveness, particularly in young children in low-...
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