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Article

Quantitative impact of pre-analytical process on plasma uracil when testing for dihydropyrimidine dehydrogenase deficiency.

British journal of clinical pharmacology - 1 Feb 2023

Maillard Maud, Launay Manon, Royer Bernard, Guitton Jérôme, Gautier-Veyret Elodie, Broutin Sophie, Tron Camille, Le Louedec Félicien, Ciccolini Joseph, Richard Damien, Alarcan Hugo, Haufroid Vincent, Tafzi Naïma, Schmitt Antonin, Etienne-Grimaldi Marie-Christine, Narjoz Céline, Thomas Fabienne

Abstract excerpt

AIMS: Determining dihydropyrimidine dehydrogenase (DPD) activity by measuring patient's uracil (U) plasma concentration is mandatory before fluoropyrimidine (FP) administration in France. In this study, we aimed to refine the pre-analytical recommendations for determining U and dihydrouracil (UH2 ) concentrations, as they are essential in reliable DPD-deficiency testing. METHODS: U and UH2 concentrations were...

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Identifiers

PMID: 36104927
DOI: 10.1111/bcp.15536
PMCID: PMC10092089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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