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COL12A1 rs970547 Polymorphism Predisposes Anterior Cruciate Ligament Injury by Inducing ER Stress and Impairing Fibroblast Function.

Advanced biology - 1 May 2026

Zhao Wenchuan, Chen Hong, Wang Junwei, Li Yixin, Chen Rui, Zhou Jingyi

Abstract excerpt

COL12A1 SNPs are linked to ACL injury risk, but functional effects are unknown. We examined COL12A1 rs970547 genotype distribution in Chinese male ACL injury patients versus controls, and its impact on collagen homeostasis and fibroblast function. ACL-derived fibroblasts with rs970547(A/A) or (A/G) were obtained from patients and controls. Collagen synthesis, COL12A1 protein stability, and ER stress were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42076899
DOI: 10.1002/adbi.202500655
PMCID: PMC13136778

Genes

COL12A1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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