Article
Sitagliptin Modulates Functional and Phenotypic Properties of Human Neutrophils Under Normal- and High-Glucose Conditions In Vitro.
Molecules (Basel, Switzerland) - 10 Apr 2026
Mališ Vanja, Drakul Marija, Rakočević Sara, Kozić Ljiljana, Dubovina Anđela, Popović Darinka, Bokonjić Dejan, Mihajlović Dušan, Čolić Miodrag
Abstract excerpt
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat type 2 diabetes. However, several studies have demonstrated its anti-inflammatory and immunomodulatory properties. The aim of this study was to investigate the effect of sitagliptin on the functional and phenotypic properties of human neutrophils under normal (NG, 5.5 mM)- and high (HG, 22 mM)-glucose conditions in vitro. Neutrophils were...
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