Article
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
Nature genetics - 1 Mar 2017
Warren Helen R, Evangelou Evangelos, Cabrera Claudia P, Gao He, Ren Meixia, Mifsud Borbala, Ntalla Ioanna, Surendran Praveen, Liu Chunyu, Cook James P, Kraja Aldi T, Drenos Fotios, Loh Marie, Verweij Niek, Marten Jonathan, Karaman Ibrahim, Lepe Marcelo P Segura, O'Reilly Paul F, Knight Joanne, Snieder Harold, Kato Norihiro, He Jiang, Tai E Shyong, Said M Abdullah, Porteous David, Alver Maris, Poulter Neil, Farrall Martin, Gansevoort Ron T, Padmanabhan Sandosh, Mägi Reedik, Stanton Alice, Connell John, Bakker Stephan J L, Metspalu Andres, Shields Denis C, Thom Simon, Brown Morris, Sever Peter, Esko Tõnu, Hayward Caroline, van der Harst Pim, Saleheen Danish, Chowdhury Rajiv, Chambers John C, Chasman Daniel I, Chakravarti Aravinda, Newton-Cheh Christopher, Lindgren Cecilia M, Levy Daniel, Kooner Jaspal S, Keavney Bernard, Tomaszewski Maciej, Samani Nilesh J, Howson Joanna M M, Tobin Martin D, Munroe Patricia B, Ehret Georg B, Wain Louise V
Abstract excerpt
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure...
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