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Article

A case of autoimmune hemolytic anemia with acquired functional mutation of the TLR7.

Immunologic research - 2 May 2026

Han Yu, Chen Hongbo, Li Ying, Yin Yuhong, Zhu Xiuxian, Wu Xiaoyan

Abstract excerpt

This article presents a case of recurrent autoimmune hemolytic anemia in a child with a gain-of-function (GOF) mutation of the TLR7. This patient's condition contrasts with the six previously documented cases of GOF mutations in the TLR7, thereby expanding the phenotypic spectrum of such mutations and enhancing clinical comprehension of childhood systemic lupus erythematosus (cSLE). The article discusses the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hematopoietic Stem Cell Transplantation

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Share to Lupus Erythematosus, Systemic

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Source

Open in PubMed Open full text

Identifiers

PMID: 42067661
DOI: 10.1007/s12026-025-09739-x
PMCID: PMC13134993

Genes

TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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