Host genetic variants in the lactose metabolism pathway associated with bifidobacterium abundance have prognostic value for immunotherapy efficacy.

Abstract excerpt

BACKGROUND AND PURPOSE: The potential predictive and therapeutic value of Bifidobacterium in immune checkpoint inhibitor (ICI) treatment has been widely studied. However, the value of its genetic determinants on the prognosis of ICI treatment remains unclear. EXPERIMENTAL APPROACH: We examined the associations between 11 single nucleotide polymorphisms (SNPs) located at host genes associated with Bifidobacterium...

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