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Sex differences in autism spectrum disorder: behavioral and sensory phenotypes in humans and mouse models.

Translational psychiatry - 1 May 2026

Noriyama Yuki, Ishida Rio, Yamamuro Kazuhiko, Kashida Natsuko, Okumura Kazuki, Okuda Mamiko, Ikehara Minobu, Toritsuka Michihiro, Saito Yasuhiko, Okada Takashi, Iwata Nakao, Makinodan Manabu

Abstract excerpt

Sex differences in autism spectrum disorder (ASD) are increasingly recognized, not only in symptom presentation but also in underlying neurobiology and response to environmental factors. However, current diagnostic practices and animal models are male-centric, overlooking female-specific phenotypes and mechanisms. We conducted a multimodal, cross-species study to assess sex-dependent ASD phenotypes. In...

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Identifiers

PMID: 42062255
DOI: 10.1038/s41398-026-04053-y
PMCID: PMC13276041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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