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Article

Replication of Endotypes in Eosinophilic Esophagitis Using a Curated Gene Panel Compared to Bulk Sequencing and Assessing Stability Over Time.

Clinical and translational gastroenterology - 1 Jul 2026

Dellon Evan S, Tsai Yihsuan S, Parker Joel S, Liu Siyao

Abstract excerpt

INTRODUCTION: It is unknown whether eosinophilic esophagitis (EoE) endotypes can be replicated using whole transcriptome data or if endotypes persist after treatment. We investigated endotypes with a curated gene panel and bulk sequencing and assessed endotype stability after topical steroid (tCS) treatment. METHODS: We analyzed specimens collected during a randomized trial of tCS for newly diagnosed EoE. Bulk...

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Identifiers

PMID: 42059451
DOI: 10.14309/ctg.0000000000001045
PMCID: PMC13400048

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