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Article

Experimental and computational methods for studying the dynamics of RNA-RNA interactions in SARS-COV2 genomes.

Briefings in functional genomics - 18 Jan 2024

Srivastava Mansi, Dukeshire Matthew R, Mir Quoseena, Omoru Okiemute Beatrice, Manzourolajdad Amirhossein, Janga Sarath Chandra

Abstract excerpt

Long-range ribonucleic acid (RNA)-RNA interactions (RRI) are prevalent in positive-strand RNA viruses, including Beta-coronaviruses, and these take part in regulatory roles, including the regulation of sub-genomic RNA production rates. Crosslinking of interacting RNAs and short read-based deep sequencing of resulting RNA-RNA hybrids have shown that these long-range structures exist in severe acute respiratory...

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Identifiers

PMID: 36752040
DOI: 10.1093/bfgp/elac050
PMCID: PMC10799312

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