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Article

Profiling SARS-CoV-2 mutation fingerprints that range from the viral pangenome to individual infection quasispecies.

Genome medicine - 19 Apr 2021

Lau Billy T, Pavlichin Dmitri, Hooker Anna C, Almeda Alison, Shin Giwon, Chen Jiamin, Sahoo Malaya K, Huang Chun Hong, Pinsky Benjamin A, Lee Ho Joon, Ji Hanlee P

Abstract excerpt

BACKGROUND: The genome of SARS-CoV-2 is susceptible to mutations during viral replication due to the errors generated by RNA-dependent RNA polymerases. These mutations enable the SARS-CoV-2 to evolve into new strains. Viral quasispecies emerge from de novo mutations that occur in individual patients. In combination, these sets of viral mutations provide distinct genetic fingerprints that reveal the patterns of...

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Identifiers

PMID: 33875001
DOI: 10.1186/s13073-021-00882-2
PMCID: PMC8054698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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