Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bone phenotype in familial partial lipodystrophy type 2: Insulin resistance and sclerostin.

Diabetes & metabolism - 1 May 2026

Dupuis Hippolyte, Jannin Arnaud, Van Es Lucille, Vankemmel Romain, Ernst Olivier, Pigny Pascal, Lion Georges, Chevalier Benjamin, Cortet Bernard, Espiard Stéphanie, Vantyghem Marie-Christine

Abstract excerpt

BACKGROUND: The impact of insulin-resistance on bone mineral density (BMD) remains unclear. Sclerostin inhibits bone formation, and increases with ageing, metabolic syndrome, and renal failure. Genetically-determined low sclerostin levels are associated with high BMD. Our aim was to determine the bone phenotype and the influence of insulin-resistance without obesity on sclerostin levels in Familial Partial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phenotype
Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Density

Share to Bone Morphogenetic Proteins

Share to Genetic Markers

Share to Insulin Resistance

Share to Lipodystrophy, Familial Partial

Share to Obesity

Source

Identifiers

PMID: 42055416
DOI: 10.1016/j.diabet.2026.101762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone phenotype in familial partial lipodystrophy type 2: Insulin resistance and sclerostin.PMID 42055416Read ↗

Association of Circulating Sclerostin Levels with Fat Mass and Metabolic Disease—Related Markers in Japanese Postmenopausal WomenSemantic proximity Read ↗

Conversations between insulin and bone: Potential mechanism of high bone density in patients with Berardinelli-Seip Congenital Lipodystrophy.Semantic proximity Read ↗

Endocrine functions of sclerostinSemantic proximity Read ↗

Partial lipodystrophy of the limbs in a diabetes clinic setting.Semantic proximity Read ↗

Negative Association Between Sclerostin and INSL3 in Isolated Human Osteocytes and in Klinefelter Syndrome: New Hints for Testis–Bone CrosstalkSemantic proximity Read ↗

Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in KuwaitSemantic proximity Read ↗

Gain-of-Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes.Semantic proximity Read ↗

Osteocyte-Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots.Semantic proximity Read ↗

Increased serum sclerostin and decreased serum IGF-1 are associated with vertebral fractures among postmenopausal women with type-2 diabetesSemantic proximity Read ↗

Wnt Signaling Genes in Adipose Tissue and Skeletal Muscle of Humans With Different Degrees of Insulin SensitivitySemantic proximity Read ↗

Gender differences in the prevalence of metabolic complications in familial partial lipodystrophy (Dunnigan variety).Semantic proximity Read ↗

Body composition phenotypes in systemic lupus erythematosus and rheumatoid arthritis: a comparative study of Caucasian female patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.