OCTN1 variants shape innate immunity and predict individual response to anti-TNFα in ulcerative colitis patients: An exploratory study.

doi:10.1093/ibd/izag061

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Article

OCTN1 variants shape innate immunity and predict individual response to anti-TNFα in ulcerative colitis patients: An exploratory study.

Inflammatory bowel diseases - 1 Jun 2026

Puca Pierluigi, Masi Letizia, Parello Simone, Poscia Andrea, Tudor Andrada Mihaela, Capobianco Ivan, Pane Cesare, Fidaleo Marco, Del Chierico Federica, Palucci Ivana, Laterza Lucrezia, Napolitano Daniele, Putignani Lorenza, Papa Alfredo, Lopetuso Loris Riccardo, Petito Valentina, Damiani Andrea, Pani Giovambattista, Scaldaferri Franco

Abstract excerpt

BACKGROUND: Ulcerative colitis (UC) exhibits substantial heterogeneity in inflammatory pathways and therapeutic response. The organic cation transporter OCTN1 (SLC22A4) and its rs1050152 missense variant (L503F) have been implicated in innate immune activation and disease susceptibility. We investigated whether OCTN1 variants modulate monocyte inflammatory responses and predict clinical outcomes in UC patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunity, Innate

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Identifiers

PMID: 42048252
DOI: 10.1093/ibd/izag061
PMCID: PMC13233138

Genes

SLC22A4

Variants

rs1050152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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OCTN1 variants shape innate immunity and predict individual response to anti-TNFα in ulcerative colitis patients: An exploratory study.PMID 42048252Read ↗

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