Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Statin-Associated Hepatotoxicity Linked to CASP8 Polymorphisms: Mechanistic Insights from Proteomic Analysis.

Yonsei medical journal - 1 May 2026

Lee Da Hoon, Park Yoon-A, Choi Seo-A, Song Yubin, Kim Jung Sun, Yee Jeong, Han Ji Min, Chang Yoonkyung, Song Tae-Jin, Gwak Hye Sun

Abstract excerpt

PURPOSE: Statins are widely used for cardiovascular diseases, but statin-associated hepatotoxicity remains a concern. Apoptotic caspases, including caspase-8 (CASP8) and caspase-3 (CASP3), are crucial in hepatotoxicity and may affect statin-associated hepatotoxicity. We examined how these gene variants affect hepatotoxicity risk and protein expression in statin users. MATERIALS AND METHODS: We retrospectively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Caspase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caspase 8

Share to Chemical and Drug Induced Liver Injury

Share to Genotype

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Polymorphism, Single Nucleotide

Share to Proteomics

Source

Open in PubMed Open full text

Identifiers

PMID: 42044984
DOI: 10.3349/ymj.2025.0181
PMCID: PMC13121787

Genes

CASP8
CASP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Statin-Associated Hepatotoxicity Linked to CASP8 Polymorphisms: Mechanistic Insights from Proteomic Analysis.PMID 42044984Read ↗

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.Semantic proximity Read ↗

The pharmacogenomics of statins.Semantic proximity Read ↗

Liver and Statins: A Critical Appraisal of the Evidence.Semantic proximity Read ↗

Pharmacogenomics of response to statin treatment and susceptibility to statin-induced adverse drug reactions in Asians: a scoping reviewSemantic proximity Read ↗

Pharmacogenomics, lipid disorders, and treatment options.Semantic proximity Read ↗

Pharmacogenomic insights into atorvastatin and rosuvastatin adverse effects: a prospective observational study in the UAE's multiethnic population.Semantic proximity Read ↗

Transporter Genes and statin-induced Hepatotoxicity.Semantic proximity Read ↗

Pharmacogenetics of Statin-Induced MyotoxicitySemantic proximity Read ↗

Pharmacogenetic Foundations of Therapeutic Efficacy and Adverse Events of StatinsSemantic proximity Read ↗

Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle ComponentsSemantic proximity Read ↗

Pharmacogenetics of statins treatment: Efficacy and safetySemantic proximity Read ↗

Association between selected gene polymorphisms and statin metabolism, risk of ischemic stroke and cardiovascular disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.