Article
The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis.
Immunological reviews - 1 Jul 2017
Otsuka Atsushi, Nomura Takashi, Rerknimitr Pawinee, Seidel Judith A, Honda Tetsuya, Kabashima Kenji
Abstract excerpt
Atopic dermatitis (AD) is a chronic skin disorder characterized by pruritus and recurrent eczematous lesions that are accompanied by T-helper (Th)2-dominated inflammation. AD Etiology is not yet completely understood, but it is multifactorial. Moreover, the disease is characterized by complex interactions between genetic and environmental factors, such as skin barrier dysfunctions, allergy/immunity, and pruritus....
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