Article
Identification of polymorphisms in the XIAP gene and analysis of association with lung cancer risk in a Korean population.
Cancer genetics and cytogenetics - 1 Jan 2008
Kang Hyo-Gyoung, Lee Su Jeong, Chae Myung Hwa, Lee Won Kee, Cha Sung Ick, Kim Chang Ho, Kam Sin, Park Rang-Woon, Kim In-San, Kim Dong Sun, Kim Young Chul, Jung Tae Hoon, Park Jae Yong
Abstract excerpt
The X-linked inhibitor of apoptosis protein (XIAP) is a potent mammalian IAP, and has been shown to play an important role in development and progression of cancer. Polymorphisms in the XIAP gene may influence XIAP production or activity, thereby modulating susceptibility to lung cancer. To test this hypothesis, we first screened for polymorphisms in the XIAP gene by direct sequencing of genomic DNA samples from...
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