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Clinical characteristics and management of Li-Fraumeni syndrome-associated lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2026

Ishioka Kota, Nishio Makoto, Ninomiya Hironori, Yanagitani Noriko, Amino Yoshiaki, Matsuura Yosuke, Nakao Masayuki, Kuga Asami, Kaneko Keika, Arakawa Hiromi, Minoura Yuko, Dobashi Akito, Habano Eri, Okumura Sakae, Mun Mingyon, Ueki Arisa

Abstract excerpt

Li-Fraumeni syndrome (LFS), caused by pathogenic germline TP53 variants, is increasingly recognized as a predisposition to lung adenocarcinoma (LUAD); however, its clinical features remain insufficiently defined. Patients diagnosed with LFS at our institution between 2000 and 2025 were retrospectively reviewed, and five patients with primary LUAD were identified among 32 individuals with LFS. The median age at...

Topics

Humans
Li-Fraumeni Syndrome
Lung Neoplasms
Female
Adult
Male
Middle Aged
ErbB Receptors
Retrospective Studies
Protein Kinase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Adenocarcinoma of Lung

Mutation

Disease Management

Source

Identifiers

PMID: 42570503
DOI: 10.1016/j.lungcan.2026.109559

Genes

EGFR
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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