Article
IXI triplet residues within the Env-V3 tip can influence the replication potential of R5-tropic HIV-1.
The journal of medical investigation : JMI - 1 Jan 2026
Le Bao Quoc, Tran Khanh Quoc, Suzuki Hirona, Okumura Nozomi, Udagawa Mei, Gotohda Chisato, Nagasaka Mari, Oyama Yuji, Doi Naoya, Adachi Akio, Koma Takaaki, Nomaguchi Masako
Abstract excerpt
The HIV-1 envelope glycoprotein (Env)-gp120 plays a critical role in viral entry by binding to the receptor CD4 and coreceptors CCR5/CXCR4. The V3 loop in CCR5-tropic HIV-1 Env-gp120 is a key domain responsible for interacting with CCR5. Based on virus mutation and adaptation studies, our structural modeling predicted that the IXI triplet residues within the V3 loop of Env-gp120 interact with hydrophobic cores in...
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