Evaluation of Serum Antibodies as Correlates of Protection Against Norovirus Infection and Disease.

doi:10.1093/infdis/jiag190

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Article

Evaluation of Serum Antibodies as Correlates of Protection Against Norovirus Infection and Disease.

The Journal of infectious diseases - 2 Sept 2026

Miller Savannah L, Billings W Zane, John Murphy, Hemme Hayley, Atmar Robert L, Bernstein David I, Shen Ye, Winter Amy K, Koelle Katia, Lopman Benjamin A, Handel Andreas

Abstract excerpt

BACKGROUND: Norovirus is a major cause of acute gastroenteritis. Several vaccines are in development. Identifying a reliable immunological correlate of protection (CoP) would aid vaccine development and evaluation; however, no strong CoP has been established to date. METHODS: We evaluated the relationships between prechallenge genogroup I, genotype 1 (GI.1) and GII.4 norovirus antibodies and clinical outcomes in...

Read the complete abstract on PubMed

Topics

Humans
Caliciviridae Infections
Norovirus
Antibodies, Viral
Gastroenteritis
Viral Vaccines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Immunoglobulin G

Bayes Theorem

Genotype

Male

Immunoglobulin A

Enzyme-Linked Immunosorbent Assay

Child, Preschool

Adult

Child

Human Challenge Trials as Topic

Adolescent

Source

Open in PubMed

Identifiers

PMID: 42007894
DOI: 10.1093/infdis/jiag190

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