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Article

Homotypic and Heterotypic Protection and Risk of Reinfection Following Natural Norovirus Infection in a Highly Endemic Setting.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 27 Jan 2021

Chhabra Preeti, Rouhani Saba, Browne Hannah, Peñataro Yori Pablo, Siguas Salas Mery, Paredes Olortegui Maribel, Moulton Lawrence H, Kosek Margaret N, Vinjé Jan

Abstract excerpt

BACKGROUND: Norovirus is a leading cause of acute gastroenteritis worldwide, yet there is limited information on homotypic or heterotypic protection following natural infection to guide vaccine development. METHODS: A total of 6020 stools collected from 299 Peruvian children between 2010 and 2014 were tested by norovirus real-time reverse-transcription polymerase chain reaction followed by sequence-based...

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PMID: 33501947
DOI: 10.1093/cid/ciaa019
PMCID: PMC7840104

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