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Article

Pan-genomic insights into resistance, virulence, and stress adaptation in Clostridium perfringens from the Tibetan Plateau.

mSphere - 26 May 2026

Luo Runbo, Wan Yanxi, Chen Wanting, Wei Hongyun, Wang Junyang, Bai Zhanchun, Li Kexin, Zhong Yanan, Ma Bin, Jin Hui, Suolang Sizhu

Abstract excerpt

Clostridium perfringens is a ubiquitous foodborne and zoonotic pathogen responsible for necrotizing enteritis, food poisoning, and gas gangrene in humans and livestock, with mortality reaching 100% in specific subtypes. The Qinghai-Tibetan Plateau, with its high altitude, hypoxia, large temperature fluctuations, and strong UV radiation, imposes a strong selective regime that drives distinctive, plateau-specific...

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PMID: 42007728
DOI: 10.1128/msphere.00792-25
PMCID: PMC13203981

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