Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiomics Biomarkers for Differential Diagnosis of Pleural Effusion: Integration of Proteomic Markers and Single-Cell Transcriptomics.

Human mutation - 1 Jan 2026

Zhang Zhengyou, Zhan Shaowei, Tang Ying, Ling Zhougui, Wu Jinyan, Rui Dong, Wei Xiaomou, Ming Moyu

Abstract excerpt

Background: Differential diagnosis of pleural effusion remains challenging despite medical thoracoscopy (MT). We investigated whether integrating proteomic biomarkers with single-cell transcriptomics and genomic mutation profiling could improve diagnostic accuracy and reveal mechanistic insights. Methods: We prospectively enrolled 564 patients with pleural effusion undergoing medical thoracoscopy. Pleural fluid...

Topics

Join the communities discussing this publication.

Diagnosis, Differential
Multiomics
Pleural Effusion
Pleural Effusion, Malignant
Proteomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Single-Cell Analysis

Single-Cell Gene Expression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 42006152
DOI: 10.1155/humu/5946608
PMCID: PMC13084142

Genes

ADA
EGFR
PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiomics Biomarkers for Differential Diagnosis of Pleural Effusion: Integration of Proteomic Markers and Single-Cell Transcriptomics.PMID 42006152Read ↗

Diagnostic molecular biomarkers for malignant pleural effusions.Semantic proximity Read ↗

Multi-omic profiling of pleural effusions: a reservoir-incubator for non-invasive insights into tumor heterogeneitySemantic proximity Read ↗

Single-cell analysis of diverse immune phenotypes in malignant pleural effusionSemantic proximity Read ↗

Molecular Profiling of Malignant Pleural Effusions with Next Generation Sequencing (NGS): Evidence that Supports Its Role in Cancer ManagementSemantic proximity Read ↗

Liquid Biopsy Based Single‐Cell Transcriptome Profiling Characterizes Heterogeneity of Disseminated Tumor Cells from Lung AdenocarcinomaSemantic proximity Read ↗

Multi-omics analysis unveils immunosuppressive microenvironment in the occurrence and development of multiple pulmonary lung cancersSemantic proximity Read ↗

High Yield of Pleural Cell-Free DNA for Diagnosis of Oncogenic Mutations in Lung Adenocarcinoma.Semantic proximity Read ↗

Single-section multiplexed imaging enables comprehensive lung cancer diagnosisSemantic proximity Read ↗

Lung adenocarcinoma with malignant serous effusions: A comprehensive clinicopathologic, molecular, and outcome analysis.Semantic proximity Read ↗

Characterization of the Immune Landscapes of Malignant Pleural Effusions and Their Corresponding Primary Tumors from Patients with Breast Carcinoma or Lung AdenocarcinomaSemantic proximity Read ↗

Multi-omics profiling with untargeted proteomics for blood-based early detection of lung cancerSemantic proximity Read ↗

Single-cell RNA sequencing captures patient-level heterogeneity and associated molecular phenotypes in breast cancer pleural effusions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.