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Article

Dysregulation of HIF-1α-regulated and thromboinflammatory genes may contribute to thrombotic risk in patients with BCR::ABL1-negative myeloproliferative neoplasms.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2026

Morath Olga, Wolfrum Therese, Crodel Carl, Hochhaus Andreas, Ernst Thomas, Rinke Jenny

Abstract excerpt

BACKGROUND: Hypoxia-inducible factor-1α (HIF-1α) regulates multiple pathways involved in metabolism, inflammation, and coagulation and may contribute to thrombotic complications in patients with BCR::ABL1-negative myeloproliferative neoplasms (MPN). OBJECTIVES: This study aimed to investigate the expression of selected HIF-1α-regulated and thromboinflammatory genes (SLC2A1, F3, SELP, VEGFA, SERPINE1, PROS1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42000137
DOI: 10.1016/j.jtha.2026.04.013

Genes

JAK2
SELP
SLC2A1
ABL1
BCR
F3
NLRP3
PROS1
SERPINE1
THBS1
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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