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Article

Genomic Structural Equation Modeling Provides an Initial View of the Genetic Architecture Related to Type 1 Gaucher Disease.

Human mutation - 1 Jan 2026

Ren Shijie, Du Mingmin, Liu Jingyuan, Li Boyu, Liu Jianping, Lang Xiaomeng

Abstract excerpt

The genetic architecture underlying traits associated with Type 1 Gaucher disease (GD1) remains insufficiently explored. We integrated genomic structural equation modeling and multiple post-genome-wide association study (GWAS) methodologies to prioritize candidate SNPs associated with GD1-related variation, identifying 15 loci with strong statistical support. Subsequently, diverse transcriptome-wide association...

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Identifiers

PMID: 41993130
DOI: 10.1155/humu/1692822
PMCID: PMC13080874

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