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Computational modelling approaches as a potential platform to understand the molecular genetics association between Parkinson's and Gaucher diseases.

Metabolic brain disease - 1 Dec 2018

Thirumal Kumar D, Eldous Hend Ghasan, Mahgoub Zainab Alaa, George Priya Doss C, Zayed Hatem

Abstract excerpt

Gaucher's disease (GD) is a genetic disorder in which glucocerebroside accumulates in cells and specific organs. It is broadly classified into type I, type II and type III. Patients with GD are at high risk of Parkinson's disease (PD), and the clinical and pathological presentation of GD patients with PD is almost identical to idiopathic PD. Several experimental models like cell culture, animal models, and...

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PMID: 29978341
DOI: 10.1007/s11011-018-0286-3

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