Article
Human peritoneal CCR2LowCRIgHigh macrophage subset exhibits embryonic origin-like phenotypes.
Human cell - 16 Apr 2026
Takahashi Naofumi, Habash Sara A, Komohara Yoshihiro, Usuki Shingo, Yasunaga Kei-Ichiro, Hino Shinjiro, Abdelnaser Randa A, Einarsdottir Thorbjorg, Nomura Takushi, Yonemura Atsuko, Ishimoto Takatsugu, Suzu Shinya
Abstract excerpt
Recent studies in mouse models have demonstrated that macrophages in adult tissues are maintained not only by the differentiation of bone marrow-derived monocytes but also by the proliferation of macrophages originating from the yolk sac or fetal liver. However, the extent to which this paradigm shift occurs in human tissues is not fully understood. In this study, we detected a human peritoneal macrophage subset...
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